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Paediatric Oncology

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Independent content
Jun 16 / Springer Healthcare
In-depth report: Paediatric Oncology
This in-depth report covers sessions on the treatment of paediatric cancers at 2021 ASCO Annual Meeting.

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Mar 16 / Roche and Genentech
Characterization of the pharmacokinetics of ▼entrectinib and its active M5 metabolite in pediatric patients with solid tumors
This poster reports the pharmacokinetics (PK) of ▼entrectinib and its active metabolite, M5 in paediatric patients with solid tumours. The findings of this study were used to support the dose recommendations for entrectinib in paediatric patients.

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Mar 9 / Roche and Genentech
Combined use of population and physiologically-based PK to support pediatric dose recommendation of ▼entrectinib
This poster presents the results of two approaches, (1) population PK modelling and (2) physiologically-based PK modelling, used to describe the PK of ▼entrectinib and its active metabolite, M5. Findings of the study were used to support the dose recommendations for entrectinib in paediatric patients.

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