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Home Neuroscience Autism Spectrum Disorder

Autism Spectrum Disorder

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May 5 / Roche and Genentech
Cross-sectional and Longitudinal Psychometric Evaluation of the Pediatric Quality of Life Inventory Generic Core Module in Autism
Caregiver-reported data examined the psychometric measurement properties of the Pediatric Quality of Life Inventory Generic Core Module (PedsQL:GC). The internal structure, convergent/divergent validity, test-retest reliability, known groups and responsiveness of PedsQL:GC were assessed.
Neuroscience Autism Spectrum Disorder INSAR-2023

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May 4 / Roche and Genentech
Expressive Communication in Naturalistic Conversations: At Home Assessment of Lexical Maturity, Morphosyntactic Complexity, and Talkativeness in Autism
Natural conversations with autistic individuals and family members in home settings were examined from the oRBiting observational study (NCT03611075). Using Expressive Language Sampling (ELS) the Expressive Communication Abilities (ECA) were quantified and the relationship between key features and clinical anchors were assessed.
Neuroscience Autism Spectrum Disorder INSAR-2023

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May 4 / Roche and Genentech
Automatic Speech Recognition for ASD Using the Open-Source Whisper Model from OpenAI
The performance of Whisper, an automatic speech recognition (ASR) model, and a commercial transcription vendor were compared to explore the ability of ASR to extract linguistic features that may correlate with a known clinical scale (Vineland Adaptive Behavior Scales [VABS-II]).
Neuroscience Autism Spectrum Disorder INSAR-2023

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May 4 / Roche and Genentech
How Learnings from the Balovaptan V1aduct Study Informed a New Drug Development Approach for the Alogabat Autism Program
Learnings from the balovaptan V1aduct study were used to inform the clinical trial design and conduct of the ongoing alogabat Aurora Borealis study. These learnings informed key study design elements such as site selection, participant eligibility, biomarker strategy, endpoint strategy, rating biases and rating quality.
Neuroscience Autism Spectrum Disorder INSAR-2023

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May 4 / Roche and Genentech
Convergence of Two Clinician-Reported Global Impression Scales in Assessing Severity and Change of Autism Symptoms
Two clinician-rated global impression scales (CGI) were compared to develop a potential new, more sensitive endpoint assessing change and severity of autism symptoms.
Neuroscience Autism Spectrum Disorder INSAR-2023

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May 4 / Roche and Genentech
Predictors of Placebo response in Three Large Clinical Trials in Autism
Predictors of placebo response in autism clinical trials were identified using three large clinical trials of balovaptan. Factors associated with an increased or decreased placebo response were identified and described.
Neuroscience Autism Spectrum Disorder INSAR-2023

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This website is intended for healthcare professionals outside the United Kingdom (UK) and Australia. Registration status and prescribing information of medicinal products may differ between countries. Please refer to local product information for any medicinal products mentioned on this website.