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Non-small Cell Lung Cancer

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May 6 / Roche and Genentech
Cough, dyspnea, chest pain or a composite? Analysis of key symptoms in metastatic non-small cell lung cancer (mNSCLC) clinical trials
Lung cancer remains the leading cause of cancer deaths worldwide. Given its highly symptomatic nature, clinical trials often focus on composite patient-reported endpoints of metastatic non-small cell lung symptoms including chest pain, cough, dyspnea, arm and shoulder pain, and general pain. This poster reports on analyzing the key symptoms in metastatic non-small cell lung cancer clinical trials.

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Apr 16 / Roche and Genentech
State-level opportunities for advancing biomarker testing in advanced non-small cell lung cancer (aNSCLC) patients with fully-insured commercial health plans
This poster shows the state-level opportunities for advancing biomarker testing in advanced non-small cell lung cancer (aNSCLC) patients with fully-insured commercial health plans.

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Apr 9 / Roche and Genentech
RNA-seq molecular subtypes and gene expression signatures in the phase 3 IMpower151 China study of 1L bevacizumab + pemetrexed/paclitaxel ± atezolizumab in metastatic NSCLC
IMpower151 (NCT04194203) is a Randomized, Double-Blind Study of Bevacizumab, Carboplatin, and Paclitaxel or Pemetrexed With or Without Atezolizumab in Chemotherapy-Naïve Patients With Stage IV Non-Squamous Non-Small Cell Lung Cancer. This poster reports on the exploratory biomarker analysis to characterize the molecular subtypes of Chinese metastatic nsqNSCLC by RNAseq and to explore the relationship between molecular subtype, predefined RNAseq signatures, PD-L1 status and clinical outcomes with ABCP and BCP.

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Nov 4 / Roche and Genentech
IMpower110: Tertiary lymphoid structures (TLS) and clinical outcomes in advanced non-small cell lung cancer (NSCLC) treated with first-line atezolizumab or chemotherapy
IMpower110 was a randomized, open-label, Phase III study evaluating first-line atezolizumab vs chemotherapy in PD-L1–selected Stage IV NSCLC. This presentation reports exploratory results of pathologist-identified tertiary lymphoid structures status and its association with clinical outcomes in IMpower110.

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Independent content
Sep 27 / Springer Healthcare
Managing ROS1 fusion-positive NSCLC in Europe and the USA
Luis Paz-Ares leads Jaime Schneider and Benjamin Besse in a discussion on the management of patients with ROS1 fusion-positive NSCLC in 2022.

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Independent content
May 19 / Springer Healthcare
The role of surgery in early-stage NSCLC management
Jessica Donington gives a surgeon’s perspective on the treatment of early-stage NSCLC in the era of targeted and immunotherapy options and the importance of helping patients to RIOT.

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Independent content
May 19 / Springer Healthcare
PD-L1 expression in early NSCLC: Interpreting the data so far
Heather Wakelee and Nasser Altorki discuss the current position on PD-L1 expression and immune checkpoint inhibition in early-stage, resectable NSCLC.

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