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Paroxysmal Nocturnal Hemoglobinuria

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Mar 6 / Roche and Genentech
Phase III Randomized COMMODORE 1 Trial: 2-Year Safety and Efficacy of Crovalimab▼ in Patients With Paroxysmal Nocturnal Hemoglobinuria (PNH) Who Switched From Eculizumab
At the primary analysis, the global, randomized, Phase III COMMODORE 1 study showed that crovalimab▼ was well tolerated and had similar exploratory efficacy in patients with paroxysmal nocturnal hemoglobinuria who switched from eculizumab to crovalimab▼ compared with those who continued receiving eculizumab. This poster reports long-term efficacy and safety data from COMMODORE 1, with a median follow-up duration of 2 years.

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Mar 6 / Roche and Genentech
Phase III Randomized COMMODORE 2 Trial: 2-Year Efficacy and Safety of Crovalimab▼ in Patients With Paroxysmal Nocturnal Hemoglobinuria (PNH) Naive to Complement Inhibition
At the primary analysis, the global, randomized, Phase III COMMODORE 2 study demonstrated the non-inferior efficacy of crovalimab▼ vs eculizumab for co-primary efficacy endpoints of hemolysis control and transfusion avoidance in patients naive to complement inhibition, with a comparable safety profile. This poster reports long-term efficacy and safety data from COMMODORE 2, with a median follow-up duration of 2 years.

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Mar 6 / Roche and Genentech
Phase III COMMODORE 1 Trial: 2-Year Efficacy and Safety of Crovalimab▼ (Crova) in Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH) Who Switched from Ravulizumab (Ravu)
The global, randomized Phase III COMMODORE 1 study showed similar safety and exploratory efficacy for crovalimab▼ vs eculizumab in randomized patients who received prior eculizumab treatment; this study also enrolled non-randomized patients who switched from ravulizumab to crovalimab▼. This poster reports efficacy and safety data from the COMMODORE 1 ravulizumab switch cohort, with a median treatment duration of approximately 2 years.

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