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Home Oncology AACR 2023
Roche and Genentech at

AACR 2023

April 14 - April 19
Orlando, USA
aacr-2023
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Medical Materials
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Apr 25 / Roche and Genentech
Phase Ib study of GDC-6036 in combination with cetuximab in patients with colorectal cancer (CRC) with KRAS G12C mutation
Safety, PK profile, and antitumour activity of divarasib (GDC-6036) in combination with cetuximab in a cohort of patients with KRAS G12C-mut colorectal cancer (21 Nov 2022 CCOD).
Oncology Colorectal Cancer AACR-2023

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Apr 19 / Roche
High resolution detection of HER2 copy number variation in admixed breast cancer cell lines and HER2+ FFPE donor tissue using a digital PCR multigene reference panel
The current gold standard method for diagnosis of copy number variation (CNV) in HER2 is IHC with concordant FISH results. Digital PCR (dPCR) has the potential to serve as a viable complementary or even alternative method by allowing direct and precise quantification of HER2 CNV. In this study, the Authors describe a multiplex assay optimized for high-resolution HER2 CNV detection using a 100,000 partition dPCR configuration. In order to evaluate clinically relevant sample types, assay performance was assessed in DNA extracted from FFPE, as well as admixed cell line DNA simulating low tumorfraction.
Oncology HealthTech Breast Cancer AACR-2023

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Apr 19 / Roche
Prediction of anti-PD-1 efficacy based on immune marker densities and their spatial distribution in metastatic colorectal carcinoma
In this Poster, the Authors display the outcome of a study assessing whether the immune contexture and spatial distribution of cells expressing immune molecules within the tumor microenvironment may predict immunotherapy outcome in patients with DNA mismatch repair (dMMR) metastatic colorectal cancer (mCRC).
Oncology Colorectal Cancer AACR-2023
12:45 PM
Duration 15mins Chapin Theater
IMbrave050: Phase 3 study of adjuvant atezolizumab + bevacizumab versus active surveillance in patients with hepatocellular carcinoma (HCC) at high risk of disease recurrence following resection or ablation
Pierce Chow, Minshan Chen, Ann-Lii Cheng, Ahmed Kaseb, Masatoshi Kudo, Han Chu Lee, Adam Yopp, Jian Zhou, Lu Wang, Xiaoyu Wen, Jeong Heo, Won Young Tak, Shinichiro Nakamura, Kazushi Numatta, Thomas Uguen, David Hsiehchen, Edward Cha, Stephen P. Hack, Qinshu Lian, Jessica Spahn, Chun Wu, Shukui Qin
Oncology | Gastrointestinal Cancer

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02:30 PM
Duration 5mins Orlando, USA
Anti-TIGIT antibody tiragolumab leverages myeloid cells and regulatory T cells to improve PD-L1 checkpoint blockade
Namrata Patil
Oncology | Lung Cancer

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02:52 PM
Duration 15mins Valencia A, Convention Center
Ovarian Cancer Tumor Microenvironment and Atezolizumab Clinical Activity: IMagyn050 sub-study
Venkatesh Krishnan, Ching-Wei Chang, Habib Hamidi, Michael Bookman, Charles Landen, Tashanna Myers, Hiroaki Kajiyama, Sakari Hietanen, Lyndsay Willmott, Premal Thaker, Cagatay Taskiran, Jalid Sehouli, Victor Khor, Yvonne G. Lin Sandro Pignata, Kathleen Moore, Luciana Molinero
Oncology | Ovarian Cancer

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This website is intended for healthcare professionals outside the United Kingdom (UK) and Australia. Registration status and prescribing information of medicinal products may differ between countries. Please refer to local product information for any medicinal products mentioned on this website.