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Home Ophthalmology Diabetic Macular Edema

Diabetic Macular Edema

DME is a vision-threatening eye condition that affects people with type 1 and type 2 diabetes, characterized by the accumulation of fluid from leaky vessels resulting in swelling of the macula, and is a leading cause of vision loss globally. Roche is committed to the development of new treatments and treatment strategies that optimize vision outcomes to improve the lives of patients and their caregivers.

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Feb 21 / Roche and Genentech
Impact of Early Intraretinal Fluid Reduction on One-Year Outcomes in Diabetic Macular Edema
This presentation describes an analysis investigating the relationship between the reduction in intraretinal fluid volume after 3 months of treatment and 2-year anatomic and visual outcomes in patients with diabetic macular edema. This post hoc analysis is based on treatment agnostic data from the phase 3 YOSEMITE and RHINE trials.
Ophthalmology Diabetic Macular Edema MACULA-SOCIETY-2025

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Feb 18 / Roche and Genentech
Retinal Fluid and Thickness Fluctuations in Pagoda Trial of PDS in Patients With DME
This presentation describes results from a post hoc analysis investigating retinal fluid and thickness fluctuations and the impact of these features on vision outcomes in patients with DME in the phase 3 Pagoda trial. In patients with DME, continuous delivery with PDS controlled retinal fluctuations and maintained vision over 48 weeks, comparable to IVT.
Ophthalmology Diabetic Macular Edema MACULA-SOCIETY-2025

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Feb 16 / Roche and Genentech
Implementation of Optimized Surgical Steps for the PDS and the Incidence of Endophthalmitis and Associated Patient Outcomes
This presentation decribes results from a retrospective analysis which examined the impact of surgical improvements on endophthalmitis incidence and patient outcomes over time in patients receiving the Port Delivery Platform with ranibizumab (PDS) in the PDS clinical development program from 2016 to 2024. A trend for improvement in endophthalmitis incidence and patient outcomes was observed after June 2020. Key updates, increased awareness, better monitoring and management in the PDS clinical trial program have all contributed to this positive trend.
Ophthalmology Neovascular Age Related Macular Degeneration Diabetic Retinopathy Diabetic Macular Edema MACULA-SOCIETY-2025

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Feb 15 / Roche and Genentech
Global Real-World Clinical and Anatomical Outcomes With Faricimab▼ in Treatment-Naïve Patients With nAMD or DME From a Multi-Country Prospective Non-Interventional Study: The VOYAGER Study
This presentation describes the results of an interim analysis of treatment-naïve patients (baseline to month 6) receiving faricimab▼ in the innovative real-world VOYAGER study. The global VOYAGER study investigates the real-world effectiveness, safety, treatment patterns and anatomical features affecting vision outcomes with faricimab▼ in patients with nAMD and DME on a global level. Treatment-naive eyes achieved visual gains and anatomic improvements during the follow-up period.
Ophthalmology Neovascular Age Related Macular Degeneration Diabetic Macular Edema MACULA-SOCIETY-2025

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Feb 15 / Roche and Genentech
Treatment Patterns, Visual Outcomes, and Safety in Eyes With nAMD and DME Treated With Faricimab▼ in the UK: 1-Year Results From the FARWIDE Study
This presentation describes results from FARWIDE nAMD and DME, a retrospective, real-world study of faricimab▼, using data from the Medisoft EMR system in the UK. Data were analyzed among treatment-naïve and previously-treated patient eyes diagnosed with nAMD or DME who started faricimab▼ after June 2022 and had at least 12 months of follow-up through July 2024. The majority of eyes had been previously treated with an anti-VEGF agent; of these most had received aflibercept 2 mg. After faricimab▼ initiation, vision improved in treatment-naïve eyes and remained stable in previously-treated eyes. Fewer injections were observed from 6 months onwards, suggesting treatment interval extension.
Ophthalmology Neovascular Age Related Macular Degeneration Diabetic Macular Edema MACULA-SOCIETY-2025

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Feb 15 / Roche and Genentech
Real-World Clinical Outcomes Update in Patients With Neovascular Age-Related Macular Degeneration (nAMD) and Diabetic Macular Edema (DME) Treated With Faricimab▼ in the US: The FARETINA Study
This presentation describes results from FARETINA nAMD and DME, a retrospective, real-world study of faricimab▼, using data from the IRIS registry in the USA. Data were analyzed among treatment-naïve and previously-treated patient eyes diagnosed with nAMD or DME who started faricimab▼ after February 2022 and had at least 12 months of follow-up through September 2024. The majority of eyes had been previously treated with an anti-VEGF agent; of these most had received aflibercept 2 mg. After faricimab▼ initiation, vision improved in treatment-naïve eyes and remained stable in previously-treated eyes. Anatomic improvement was observed in both cohorts. Fewer injections were observed from 6 months onwards, suggesting treatment interval extension.
Ophthalmology Neovascular Age Related Macular Degeneration Diabetic Macular Edema MACULA-SOCIETY-2025
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This website is intended for healthcare professionals outside the United Kingdom (UK) and Australia. Registration status and prescribing information of medicinal products may differ between countries. Please refer to local product information for any medicinal products mentioned on this website.