I am a healthcare professional

Notice


Welcome to MEDICALLY. This website is a non-promotional international resource intended to facilitate transparent scientific exchange regarding developments in medical research and disease management. It is intended for healthcare professionals outside the United Kingdom (UK) and Australia. The content on this website may include scientific information about experimental or investigational compounds, indications and services that are not approved or valid in your jurisdiction. Registration status and prescribing information of medicinal products may differ between countries. Roche and Genentech do not support, endorse or recommend the unapproved use of any compound or service in your jurisdiction, including those discussed on this website.


Please refer to local product information for any medicinal products mentioned. Information available on this website does not constitute professional medical advice, and Roche and Genentech accept no responsibility for access to or use of the same. Healthcare professionals outside the US are required to register and log-in to access the full range of content available on this website.


By clicking on one of the healthcare professional buttons below, you acknowledge you have read and understood this message and that you are requesting access to MEDICALLY. If you are not a healthcare professional, please use the other links below to access information relevant to you.


Cookies


We use cookies on this site to enable the site to function properly and to enhance your user experience. Cookies are files stored in your browser, which most websites use to personalize your web experience. Your information will only be used to provide information that is relevant to you. It will not be used for any other purpose. If you wish to restrict or block cookies, which are set on your device, then you can do this through your browser settings.


You can find out more about cookies by browsing our Privacy Policy.

 

I am a healthcare professional
(outside the UK and Australia):

Not a healthcare professional? For individuals outside the US, browse Roche's patient website or roche.com. For individuals in the US, browse gene.com.

External site

By following this link, you are leaving Medically and entering a website that is not owned or controlled by Roche. Roche does not take any responsibility for access to or use of this website, nor for any content therein.

Leave site
Jun 15 / Springer Healthcare

2020 Annual Meeting In-Depth Report: Colorectal Cancer

Description

This in-depth report of the American Society of Clinical Oncology Annual Meeting 2020 outlines and discusses recent research in colorectal cancer.

American Society of Clinical Oncology 2020 ASCO Annual Meeting

May 29–31st, 2020

In-Depth Report: Colorectal Cancer

 

The Annual Meeting of the American Society of Clinical Oncology (ASCO), now in its 56th year, took place under a new virtual format on 29–31 May 2020. Opening the meeting, ASCO President Howard A. “Skip” Burris III highlighted that although COVID-19 had changed the format of this year’s ASCO 2020, the collective determination to make progress against cancer was as strong as ever.


ASCO President Howard A. “Skip” Burris III

Dr Burris explained that the COVID-19 pandemic has changed the way patients with cancer receive care and has encouraged healthcare professionals in the oncology community and their patients to weigh the risks and benefits of delaying treatment.

Dr Burris highlighted that data on how COVID-19 was impacting patients was being collected through the new ASCO Registry and CancerLinQ database, which this year crossed a milestone of 2.5 million patients.

As ever, this year’s ASCO meeting aimed to enable clinicians to understand how and when to integrate novel research into patient care. Dr Burris noted that the galvanising theme of the ASCO20 Virtual Scientific Program – “Unite and Conquer: Accelerating Progress Together” – would take on even more resonance given the extraordinary times as ASCO’s global audience learnt about new developments in cancer care.

The world is grappling with a pandemic and we are all readjusting to a new reality, but it cannot stop us. We, the ASCO Community, are absolutely unwilling to let anything stop us in the fight against cancer.”

Howard A. “Skip” Burris III, ASCO President

Colorectal Cancer

Metastatic Colorectal Cancer


PFS duration in patients with mCRC treated with pembrolizumab versus standard therapy

High-level microsatellite instability (MSI-H) metastatic colorectal cancer (mCRC) typically demonstrates a poor response to conventional chemotherapy. Defects in DNA mismatch repair resulting in MSI generate a high tumour mutation burden (TMB), a wealth of tumour neoantigens and increased immune cell infiltration, offering up a novel means of controlling MSI-H mCRC through the use of immune checkpoint inhibitor therapy. Thierry André, Sorbonne University and Saint-Antoine Hospital, Paris, France, presented data from the Phase III KEYNOTE-177 study which demonstrated that among patients with mCRC featuring MSI-H, first-line treatment with single-agent pembrolizumab doubled progression-free survival (PFS) compared with chemotherapy-based therapy and also reduced the incidence of severe toxicities by two-thirds (Abstract LBA4; NCT02563002).

The median PFS reached 16.5 months with pembrolizumab versus 8.2 months with standard therapy. In addition, 48% of patients who received pembrolizumab remained alive and free of progressive disease at 2 years compared with only 19% of patients who received chemotherapy (modified FOLFOX or FOLFIRI) plus or minus bevacizumab or cetuximab. Overall survival (OS) data are still awaited.

“Data from KEYNOTE-177 demonstrate that the majority of those 5% of patients with mCRC selected by MSI-H status benefited greatly from pembrolizumab compared with standard-of-care.”

Thierry André, Sorbonne University and Saint-Antoine Hospital, Paris, France

Michael J. Overman, The University of Texas MD Anderson Cancer Center, Houston, USA, highlighted the practice-changing nature of these data, along with the need to test all patients with mCRC for mismatch repair or microsatellite status. However, Dr Overman noted that pembrolizumab displayed a higher rate of disease progression than chemotherapy which suggested that almost one-third of patients were demonstrating intrinsic resistance to PD-1-based therapy and therefore not benefitting from pembrolizumab. Thus, identifying patients with biomarkers of resistance remains critical to allow these individuals to avoid ineffective treatment.

Median PFS in elderly patients with mCRC

Data on first-line treatment efficacy in elderly patients with mCRC are limited, with many analyses adopting a cut-off of 65 years of age, and specific evidence with anti-epidermal growth factor receptors (EGFRs) remains low. While FOLFOX-panitumumab is one option for RAS wild-type (wt) treatment-naïve patients with mCRC, data from the Phase II PANDA study suggest that fluorouracil/leucovorin plus panitumumab for up to 12 cycles followed by panitumumab maintenance until progressive disease might be a reasonable treatment option in elderly patients with mCRC presenting with RAS/BRAF wt tumours according to Sara Lonardi, Veneto Institute of Oncology (IOV)-IRCCS, Padua, Italy (Abstract 4002; NCT02904031). Phase III studies are now warranted.

“Large prospective randomised studies in molecularly selected elderly mCRC patients are feasible with multicentre collaborative efforts.”

Sara Lonardi, Veneto Institute of Oncology (IOV)-IRCCS, Padua, Italy

Closing Remarks

In response to the COVID-19 pandemic, ASCO completely reimagined and reinvented its 2020 Annual Meeting by delivering a successful virtual meeting. This virtual platform still had the aim of achieving an engaging and educational meeting experience for participants from around the world. Delegates were able to view data, clinical experiences, patient perspectives and best practices that will hopefully stimulate new ways of thinking and ultimately translate into optimal patient care within the oncology field.

 

©Springer Healthcare 2020. This content has been independently selected and developed by Springer Healthcare and licensed by Roche for Medically. The topics covered are based on therapeutic areas specified by Roche. Inclusion or exclusion of any product does not imply its use is either advocated or rejected. Use of trade names is for product identification only and does not imply endorsement. Opinions expressed do not reflect the views of Springer Healthcare. Springer Healthcare assumes no responsibility for any injury or damage to persons or property arising out of, or related to, any use of the material or to any errors or omissions. Please consult the latest prescribing information from the manufacturer for any products mentioned in this material.