Safety and efficacy of semorinemab in prodromal-to-mild Alzheimer’s disease: Preliminary analyses of the Phase 2 Tauriel study

This presentation will provide preliminary data from the Phase II Tauriel study. Tauriel enrolled participants aged 50-80 years with prodromal or mild Alzheimer's disease (AD), with evidence of cerebral amyloid pathology (amyloid PET or Elecsys® β-Amyloid(1–42) cerebrospinal fluid immunoassay). Participants were randomized to receive semorinemab at 1500, 4500, or 8100 mg IV or placebo IV every 2 weeks for doses 1–3 and every 4 weeks thereafter for 72 weeks. Primary analyses were conducted at Week 73. The primary endpoint was change in CDR-SB from baseline.

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