PI3K/AKT pathway biomarkers analysis of the Phase III IPATential150 trial of ipatasertib plus abiraterone in metastatic castration-resistant prostate cancer

This presentation reports an exploratory analysis of the IPATential150 study focusing on putative biomarkers and their correlation with clinical efficacy. This study evaluated how PI3K/AKT pathway alterations impacted outcomes with ipatasertib and abiraterone versus placebo and abiraterone in first-line metastatic castration-resistant prostate cancer, a population with poor prognosis.

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