A Phase Ib Study to Evaluate RO7198457, an Individualized Neoantigen Specific Immunotherapy (iNeST), in Combination With Atezolizumab▼ in Patients With Locally Advanced or Metastatic Solid Tumors

RO7198457 is a systemically administered RNA-lipoplex individualized neoantigen specific immunotherapy (iNeST) designed to stimulate T cell responses against neoantigens. A first-in-human Phase Ib study of RO7198457, in combination with the aPD-L1 antibody atezolizumab▼ is being conducted in patients with locally advanced or metastatic solid tumors. Safety, tolerability, pharmacodynamic activity, and preliminary anti-tumor activity are presented in this oral presentation.


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