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Phase Ia/Ib Dose-Escalation Study of the Anti-TIGIT Antibody Tiragolumab as a Single Agent and in Combination with Atezolizumab in Patients with Advanced Solid Tumors

Tiragolumab is a fully human IgG1/kappa anti-TIGIT monoclonal antibody with an intact Fc region that blocks the binding of TIGIT to its ligand PVR and to the co-activating receptor CD226. GO30103 is a first in-human Phase I study of tiragolumab as a single agent (Phase Ia) and in combination with the anti-PD-L1 antibody atezolizumab (Phase Ib) in patients with advanced solid tumors. Safety, tolerability, pharmacokinetics, pharmacodynamics, and preliminary anti-tumor activity are presented in this oral presentation.

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