Avastin and Use of an In-Line Filter

This article responds to your request for information on Avastin® (bevacizumab) and the use of in-line filters.


Avastin is formulated as a liquid concentrate for an infusion solution and does not require reconstitution.


There is no requirement to use an in-line filter during Avastin administration. The use of an in-line filter is not recommended by Roche.


During the manufacturing process, the Avastin bulk product is pre-filtered with sterile 0.22 micron filter with a PVDF (polyvinylidene difloride) membrane.[1]

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Last updated August 15, 2023


  1. Roche Internal Technical Document (Accessed July 2023). 

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