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Kadcyla and Solutions for Reconstitution and Dilution

This article responds to your request for information on Kadcyla® (trastuzumab emtansine) and compatibility with solutions for reconstitution and dilution.

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Last updated December 04, 2023

Kadcyla lyophilised powder should be reconstituted with sterile water according to the vial size and volume presented in Table 1.[1] The reconstituted solution should be further diluted with 0.9% NaCl or 0.45% NaCl.[1]

Table 1. Sterile water volume for reconstitution

For vial size 100mg vial and 160mg vial volume of sterile water is 5mL and 8mL

If Kadcyla was inadvertently reconstituted or diluted with a solution other than as described in the prescribing information, contact your local medical information service.

Precaution against using dextrose 5% solution

Roche recommends against reconstituting or diluting with dextrose (or glucose) 5% solution as it causes aggregation of the protein.[1]

Precaution against admixtures

Kadcyla should not be reconstituted, diluted, or mixed with other drugs.[1]


1. Roche Internal Regulatory Report. Accessed 12 July 2023.

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