Unopened vial

Kadcyla vials should be stored at 2°C to 8°C.[1]

If Kadcyla was inadvertantly stored outside of this temperature range, a stability assessment can be requested through medinfo.roche.com.

Reconstituted solution

Kadcyla vials reconstituted with sterile water for injection should be used immediately following reconstitution.[1] If not used immediately, the reconstituted vials can be stored for up to 24 hours at 2°C to 8°C and must be discarded thereafter.

Do not freeze the reconstituted solution.

Infusion bag containing the diluted solution

The reconstituted Kadcyla solution diluted in 0.9% NaCl Injection, or 0.45% NaCl Injection, may be stored at 2°C to 8°C for up to 24 hours prior to use.[1]

Do not freeze the solution for infusion containing the reconstituted product.

Avoid exposing Kadcyla to direct daylight in all forms, including in the unopened vial, reconstituted solution, and diluted infusion bag.[2] Handling of Kadcyla in ambient light conditions is acceptable. Refer to the locally approved prescribing information for any additional storage recommendations.[2]

1. Roche Internal Regulatory Report. Accessed 12 July 2023.

2. Roche Internal Communications. Accessed 25 July 2023.