Kadcyla Storage Recommendations
This article responds to your request for information on Kadcyla® (trastuzumab emtansine) and storage recommendations.
Last updated June 10, 2026
Recommendations for Kadcyla storage temperature
Unopened vial
Kadcyla vials should be stored at 2°C to 8°C.[1]
If Kadcyla was inadvertently stored outside of this temperature range, a stability assessment can be requested through medinfo.roche.com.
Reconstituted solution
Kadcyla vials reconstituted with sterile water for injection, or 0.45% NaCl Injection, should be used immediately following reconstitution.[1] If not used immediately, the reconstituted vials can be stored for up to 120 hours (5 days) at 2°C to 8°C and must be discarded thereafter.
Do not freeze the reconstituted solution.
Infusion bag containing the diluted solution
The reconstituted Kadcyla solution diluted in 0.9% NaCl Injection, or 0.45% NaCl Injection, may be stored at 2°C to 8°C for up to 24 hours prior to use.[1]
Do not freeze the solution for infusion containing the reconstituted product.
Once the prepared infusion solution has been stored in the refrigerator, it should be administered immediately after it has reached room temperature, in accordance with the instructions in the summary of product characteristics regarding the specified infusion rates (90 minutes for the initial dose and 30 minutes for subsequent infusions).[2]
Recommendation for Kadcyla light protection
Avoid exposing Kadcyla to direct daylight in all forms, including in the unopened vial, reconstituted solution, and diluted infusion bag.[3] Handling of Kadcyla in ambient light conditions is acceptable. Refer to the locally approved prescribing information for any additional storage recommendations.[3]
References
1. Roche Internal Regulatory Report (Kadcyla CDS v14.0)
2. Roche Internal Technical Report (TEC-0212256)
3. Roche Internal Communications. Accessed 26 May 2026.
Medinfo
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