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Wearable Device Outcomes From EMBARK, a Pivotal Phase 3 Study in Patients With Duchenne Muscular Dystrophy Treated With Delandistrogene Moxeparvovec

Authors Paul Strijbos, Craig McDonald, Alexander Murphy, Stefanie Mason, Xiao Ni, Carol Reid, Marianna Manfrini, Jacob Elkins, Louise Rodino-Klapac, Francesco Muntoni

Published date19 November, 2024

We present analyses of wearable-derived ambulation endpoints from EMBARK Part 1 (52 weeks), including Stride Velocity 95th Centile (SV95C; secondary endpoint) and exploratory ambulation endpoints. Results demonstrated improved disease trajectories following treatment with delandistrogene moxeparvovec and supported stabilization or slowing of DMD disease progression compared with placebo, consistent with secondary functional endpoints in EMBARK.

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