This study compared differences in data generated by the AVENIO Tumor Tissue CGP Kit and the TruSight Oncology 500 (TSO) assay - two commercially available pan-cancer solutions. Potential clinical implications of the data generated by both products is presented. Variant calls were acquired using manufacturer-provided software; key variant annotation outputs were variant tiers and ESMO Scale for Clinical Actionability of molecular Targets (ESCAT) guideline inclusion per tumour type. Differences in the detection of tumour mutational burden and ESCAT biomarkers, including copy number alterations, were identified.
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