Conceptualization of core clinico-molecular variables for registries enrolling patients diagnosed with a solid tumor and profiled with next-generation sequencing (NGS)

This study proposes a framework for identifying the core variables that are most critical for solid tumor-based, real-world studies and registries in precision oncology. Mandatory and optional variables are described, as well as recommendations for vocabularies to use, which will provide viable guidance for conducting research- and regulatory-grade real-world precision oncology studies, and facilitating standardized data collection and thus pooling from various datasets.


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