Knowing a patient’s biomarker profile can inform treatment decisions and open up
new targeted therapy options1–3
High-quality next-generation sequencing (NGS) helps you see beyond the tumour origin to exactly which mutations are driving that cancer.4
What’s changing5,6
Targeted therapies are being studied to advance treatment options for patients with actionable biomarkers7,8
High-quality NGS can help inform treatment decisions and open up new targeted therapy options for patients1,9,25,26
Precision medicine expands treatment options and approaches for patients, including traditional cancer therapies and emerging targeted therapies, with the aim of achieving the best possible outcome for the patient5
CNS, central nervous system; NGS, next-generation sequencing; NSCLC, non-small cell lung cancer.
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Non-Small Cell Lung Cancer. V.6.2020, 2020. Available at: https://www.nccn.org/professionals/physician_gls/pdf/nscl.pdf (Accessed November 2020).
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11. National Comprehensive Cancer Network. NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines). Acute Myeloid Leukemia. V.1.2021, October 14 2020. Available at: https://www.nccn.org/professionals/physician_gls/pdf/aml.pdf (Accessed November 2020).
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14. Leonetti A, et al. Cancer Treat Rev 2018;66:82–94.
15. European Society for Medical Oncology. BRAF in Colorectal Cancer: ESMO Biomarker Factsheet. Available at: https://oncologypro.esmo.org/Education-Library/Factsheets-on-Biomarkers/BRAF-in-Colorectal-Cancer (Accessed November 2020).
16. Dearden S, et al. Ann Oncol 2013;24:2371–2376.
17. Tsao S, et al. J Thorac Oncol 2016;11:613–638.
18. European Society for Medical Oncology. HER2 in Breast Cancer: ESMO Biomarker Factsheet. Available at: https://oncologypro.esmo.org/Education-Library/Factsheets-on-Biomarkers/HER2-in-Breast-Cancer (Accessed November 2020).
19. Sakabe T, et al. Oncol Lett 2017;13:3703–3708.
20. Bergethon K, et al. J Clin Oncol 2012;30:863–870.
21. Dugay F, et al. Oncotarget 2017;8:53336–53351.
22. Davies K, Doebele RC. Clin Cancer Res 2013;19:4040–4045.
23. Lin J, Shaw A. J Thorac Oncol 2017;12:1611–1625.
24. Okamura R, et al. JCO Precis Oncol 2018;2018.
25. Gagan J, Van Allen EM. Genome Med 2015;7:80.
26. Suh JH, et al. Oncologist 2016;21:684–691.
27. Drilon A, et al. Clin Cancer Res 2015;21:3631–3639.
28. Rankin A, et al. Oncologist 2016;21:1306–1314.
29. Ross JS, et al. Cancer 2016;122:2654–2662.
30. Hirshfield KM, et al. Oncologist 2016;21:1315–1325.
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