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Home Neuroscience CTAD 2025
Roche and Genentech at

CTAD 2025

December 01 - December 04
San Diego, USA / Virtual (Hybrid)
ctad-alzheimer.com
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Medical Materials
Agenda
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11:00 PM
Duration 60mins San Diego, USA
REACHED – a pilot study exploring electronic health records and digital assessments to identify potential participants from understudied populations for clinical studies in Alzheimer’s disease
Alexandria Wise-Brown, Erin Beck, Frank Boess, Frank Perilli, Giuseppe Filosa, Ira Goodman, Janice Smith, Kelly Coultes, Nicola Antonio Maiorano, Ruth Croney
Neuroscience | Alzheimer Disease

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01:35 AM
Duration 8mins San Diego, California, USA
Brainshuttle™ AD: New interim results of a randomized, placebo-controlled Phase Ib/IIa proof-of-concept study with trontinemab, a novel anti-amyloid monoclonal bispecific antibody for the treatment of Alzheimer’s disease
Luka Kulic, Fabien Alcaraz, Gregory Klein, Stephen Salloway, Carsten Hofmann, João A. Abrantes, Denise Sickert, Jakub Wojtowicz, Ruth Croney, David Agnew, Silke Ahlers, Paul Delmar, Hanno Svoboda
Neuroscience | Alzheimer Disease

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Duration 8mins San Diego, California, USA
TRONTIER 1 and 2: rationale and design of two identical Phase III trials to assess the efficacy and safety of trontinemab in early symptomatic Alzheimer’s disease
Catherine Mummery, Janice Smith, Jeffrey L. Cummings, Gil Rabinovici, Stephen Salloway, Reisa Sperling, Henrik Zetterberg, Angeliki Thanasopoulou, Christopher Lane, Paul Delmar, Gregory Klein, Carsten Hofmann, Luka Kulic
Neuroscience | Alzheimer Disease

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Duration 8mins San Diego, California, USA
The TRAVELLER master pre-screener protocol: An approach to reduce participant burden and broaden access to clinical trials in Alzheimer’s disease
Christopher Lane, Angeliki Thanasopoulou, Teresa Gleissl, Ross Paterson, Christina Rabe, Derrek Hibar, Alina Bauer, Imke Kirste, Annunziata Di Domenico, Tobias Bittner, Ruth Croney, Janice Smith
Neuroscience | Alzheimer Disease

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03:30 PM
Duration 60mins San Diego, USA
Enhancing Alzheimer's Disease Diagnostic Efficiency and Accuracy with Plasma-Based pTau217 Testing: A Comparative Analysis in Primary and Secondary Care
Sophie ROTH, Martin GUESS, Gustaf ORTSÄTER
Neuroscience | Alzheimer Disease

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12:20 AM
Duration 15mins San Diego, California, USA
Pharmacokinetic / Pharmacodynamic Relationship of the Gamma-Secretase Modulator Nivegacetor in Presymptomatic Carriers of the PSEN1 E280A Mutation
Rosanna Tortelli, Agnès Poirier, Enrique Gaspar, Dominik Lott, Stella Yilmaz, Tianxu Yang, Agnès Portron, Kalbinder Mahil, Tayo Bodede, David Aguillón, David Gordon, Robert Alexander, Thomas Mueggler, Stefan Sturm, Irene Gerlach
Neuroscience | Alzheimer Disease

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03:15 PM
Duration 60mins San Diego, USA
Comprehensive Biomarker Assessment of the Gamma-Secretase Modulator Nivegacetor in Presymptomatic Carriers of the PSEN1 E280A Mutation
Agnès Poirier, Enrique Gaspar, Gwendlyn Kollmorgen, Dominik Lott, Stella Yilmaz, Tianxu Yang, Agnès Portron, Kalbinder Mahi, Tayo Bodede, David Aguillón, David Gordon, Robert Alexander, Thomas Mueggler, Rosanna Tortelli, Irene Gerlach
Neuroscience | Alzheimer Disease

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06:10 PM
Duration 15mins San Diego, California, USA
Brain volume changes with gantenerumab: relationship with amyloid removal
Matteo Tonietto, Christopher Belder, Frederik Barkhof, Gregory Klein, Janice Smith, Nick Fox
Neuroscience | Alzheimer Disease

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12:40 AM
Duration 15mins San Diego, California, USA
Population characteristics and implications of implementation strategies for blood-based biomarkers in Alzheimer’s disease across healthcare settings: Insights from a prospective, global, multicenter study
Clara Quijano Rubio, Craig Ritchie, Imke Kirste, Jeffrey Dage, Kristian Steen Frederiksen, Marc Suarez Calvet, Marwan Sabbagh, Sayuri Hortsch
Neuroscience | Alzheimer Disease

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03:15 PM
Duration 60mins San Diego, USA
Automated linguistic and acoustic metrics of a smartphone-captured cued narration and recall assessment for detecting early memory and biomarker changes in early symptomatic AD
Raphael M. Ullmann, Arnaud M. Wolfer, Kami Kosek, Monika Zbytniewska-Mégret, Thanneer M. Perumal, Irma T. Kurniawan & Kirsten I. Taylor
Neuroscience | Alzheimer Disease

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08:20 PM
Duration 15mins San Diego, California, USA
Breaking barriers in early Alzheimer's disease diagnosis: the power of the in vitro diagnostic Elecsys pT181p immunoassay in a population reflective of real-world clinical practice
Anna Burke, Christopher Rowe, Clara Quijano Rubio, Dag Aarsland, David Caley, Mark Rapp, Patrick Menzel, Sayuri Hortsch
Neuroscience | Alzheimer Disease

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10:50 PM
Duration 15mins San Diego, California, USA
Clinical performance of the Elecsys CSF pTau181/Aβ42 ratio for concordance with tau-PET in two independent cohorts
Ruben Smith, Leslie Shaw, Sebastian Palmqvist, Niklas Mattsson-Carlgren, Gregory Klein, Matteo Tonietto, Clara Quijano-Rubio, Christopher M. Rank, Myrto Andreadou, Samantha C. Burnham, Erik Stomrud
Neuroscience | Alzheimer Disease

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