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Cystic Fibrosis

Cystic fibrosis is characterised by widespread dysfunction of exocrine glands which results in a broad array of presenting manifestations and complications.

Secretions from mucous glands in the lungs and gastrointestinal tract are physically altered, becoming unusually thick and viscous. Clinical complications associated with these changes include the development of chronic suppurative bronchitis with destruction of lung tissue, pancreatic insufficiency leading to malabsorption, diabetes mellitus, liver disease and male infertility.

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