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ECTRIMS 2024

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Coming soon
06:00 AM
Duration 72hrs Copenhagen, Denmark
Smartphone-based assessment of gait with Floodlight in multiple sclerosis shows sensitivity to change over a follow-up period of 3 years
João Rodrigues, Guy Bogaarts, Andrea Festanti, Cedric Simillion, Stanislas Hubeaux, Vittorio P Illiano, Letizia Leocani, Marisa P McGinley, Maria P Sormani, Giancarlo Comi, Agne Kazlauskaite, Licinio Craveiro, Mike D Rinderknecht, Mattia Zanon, Helmut Butzkueven

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01:00 PM
Duration 10mins Room A3
Evaluation of CHIT1 and SERPINA3 as candidate cerebrospinal fluid biomarkers of progressive biology in multiple sclerosis
Amit Bar-Or, Jeffrey M. Gelfand, Chinaza Agbim, H. Christian von Buedingen, Briana Cameron, Ann E. Herman, Xiaoming Jia, Akshaya Ramesh, Ryan C. Winger, Jenny Jiang, Christopher Harp, Anne H. Cross

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Duration 10mins Room A3
Long-Term Effect of Ocrelizumab on Brain Volume and Lesion Activity Outcomes in Patients with Relapsing Multiple Sclerosis: Analysis of 10-Year Data from the OPERA Trials
Granziera C, Kolind S, Traboulsee A, Hauser S, Bonati U, Wang Q, von Buren G, Clayton D, Craveiro L, Arnold DL

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Duration 10mins Room A3
Reduced cerebrospinal fluid biomarkers (neurofilament light chain, B cells, T cells) and improved clinical/imaging assessments of disease activity are sustained after 5 years of ocrelizumab treatment: long-term extension results from OBOE
Anne Cross, Jeffrey Gelfand, H. Christian von Buedingen, David Clayton, Briana Cameron, Ann E. Herman, Xiaoming Jia, Chris Harp, Ryan Winger, Amit Bar-Or

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01:04 PM
Duration 7mins Room A1
Ocrelizumab Dose Selection for Treatment of Pediatric Relapsing-Remitting Multiple Sclerosis: Pharmacokinetic, Safety, and Efficacy Results From OPERETTA 1 (NCT04075266)
Kotulska K, Valeriani M, Mar S, Steinborn B, Schreiner T, Waubant E, Filippi M, Mazurkiewicz-Beldzinska M, Manilus C, Campos N, Peill E, Kletzl H, Lin CJ, El-Azzouzi B, Shen YA, Banwell B

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02:15 PM
Duration 2hrs Copenhagen, Denmark
B cell levels and placental transfer in infants potentially exposed to ocrelizumab during pregnancy: Analysis of the Phase IV MINORE study
Hellwig K, Bove R, Dobson R, Vukusic S, Oreja-Guevara C, McElrath T, Pietrasanta C, Maillart E, Jacobs D, Pasquarelli N, Lin CJ, Craviero L, Zecevic D, Kazlauskaite A, Raposo C

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Duration 2hrs Copenhagen, Denmark
Pregnancy and infant outcomes in women with multiple sclerosis receiving ocrelizumab: Analysis of approximately 4,000 pregnancies to date
Dobson R, Vukusic S, Bove R, Hellwig, K, Krysko KM, Pietrasanta C, McElrath T, Craveiro L, Ferreira G, Goncalves Pereira Alves D, Zecevic D, Lin CJ, Pasquarelli N, Oreja-Guevara C

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Duration 3hrs Copenhagen, Denmark
Safety of ocrelizumab in multiple sclerosis: Up to 11 years of updated analysis in patients with relapsing and progressive multiple sclerosis
Hauser SL, Kappos L, Montalban X, Chognot C, Pasquarelli N, Punia V, Incera E, El Azzouzi B, Wolinsky JS

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Duration 2hrs Copenhagen, Denmark
Clinical outcomes among persons with relapsing multiple sclerosis initiating first-line treatment with ocrelizumab: Insights from real-world studies MSBase OCR-R substudy, MuSicalE and CONFIDENCE
Butzkueven H, Hobart J, Bluemich S, Buttmann M, Camerlingo S, Craveiro L, Cutter G, Farr P, Meuth S, Muros-Le Rouzic E, Rovira A, Spelman T, Trojano M, van der Walt A, Weber M, Ziemssen T

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Duration 2hrs Copenhagen, Denmark
Multiple Sclerosis Progression Prediction Based on Machine Learning
Ghazaleh N, Baker M, Overell J

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12:01 AM
Duration 24hrs Copenhagen, Denmark
Anti-IL-6 receptor antibody attenuates myelitis severity of AQP4 peptide immunized mice
Katsura Y, Miyake S, Baba M, Tomizawa-Shinohara H, Matsumoto Y, Serizawa K

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08:10 AM
Duration 10mins Room A2
B-cell levels and breastmilk transfer in infants of lactating women with multiple sclerosis treated with ocrelizumab: Primary results of the prospective, multicentre, open-label, phase IV study SOPRANINO
Bove R, Oreja-Guevara C, Hellwig K, Vukusic S, Shah A, Graham E, McElrath T, Pietrasanta C, Kletzl H, Kazlauskaite A, Zecevic D, Raposo C, Craviero L, Lin C-J, Pasquarelli N, Dobson R

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02:45 PM
Duration 2hrs Copenhagen, Denmark
Fenebrutinib maintains low disease activity in relapsing multiple sclerosis: results from the FENopta trial open-label extension
Amit Bar-Or, Jiwon Oh, Michal Dufek, Hrvoje Budincevic, Mario Habek, Maresa Caunt, Piia Thomas, Malgorzata Sierzega, David Clayton, Ying-Fang Chen, John N. Ratchford, Alexandra Goodyear, Jelena Drulovic

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Duration 2hrs Copenhagen, Denmark
Exposure-response analysis of fenebrutinib in patients with relapsing multiple sclerosis
Denison Kuruvilla, Michelle Deng, Anita Moein, Malgorzata Sierzega, Qi Qi, Alexandra Goodyear, Lin Pan, Nastya Kassir, Maria-Pia Sormani, Gavin Giovannoni, Yan Xu

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Duration 2hrs Copenhagen, Denmark
Elucidating the potential of Fenebrutinib, a noncovalent and reversible Bruton's tyrosine kinase inhibitor, to modulate microglial inflammation in human brain cell systems
Julie Langlois, Simona Lange, William Macnair, Martin Ebeling, Roland Schmucki, Jonathan DeGeer, Tania Sudharshan, Yun-An Shen, Christopher Harp, Ludovic Collin, James Keaney

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Duration 2hrs Copenhagen, Denmark
Early treatment with ocrelizumab: a multicentre, real-world observational study
Enrique Alvarez, Robert T. Naismith, Le H. Hua, Nicole G. Bonine, Ryan C. Winger, Hela Romdhani, Annie Guérin, Mohira Lévesque-Leroux, Gayatri Marathe, Daniel Ontaneda

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Duration 2hrs Copenhagen, Denmark
Two-year analysis of efficacy and safety data from Black and Hispanic people with relapsing multiple sclerosis receiving ocrelizumab treatment in the CHIMES trial
Nancy L Monson, Gregory F. Wu, Fernando Cuascut, Lilyana Amezcua, Williams, Mitzi, Bertnitsas, Evanthia, Anthony T Reder, Hooker, Juzar, Dilraj Sokhi, Nourbaksh, Bardia, Ahmed Obeidat, Harp, Christopher, Pei, Jinglan, Abioye, Ibraheem, Timothy Vartanian

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Duration 2hrs Copenhagen, Denmark
Smartphone-based assessment of gait with Floodlight in multiple sclerosis shows high operational robustness and analytical validity against reference tool
Natan Napiórkowski, Lorenza Angelini, Dimitar Stanev, Rafal Klimas, Marta Plonka, Gabriela Gonzolez Chan, Lisa Bunn, Paul S Glazier, Jonathan Marsden, Jeremy Hobart, Licinio Craveiro, Mattia Zanon, Mike D Rinderknecht

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Duration 2hrs Copenhagen, Denmark
Smartphone-based assessment of gait with Floodlight shows agreement with clinical measures of disability and gait impairment in multiple sclerosis
Andrea Festanti, Dimitar Stanev, Lorenza Angelini, Marta Plonka, Natan Napiórkowski, Rafal Klimas, Stanislas Hubeaux, Richard Hosking, Letizia Leocani, Giancarlo Comi, Agne Kazlauskaite, Helmut Butzkueven, Jeremy Hobart, Licinio Craveiro, Jonathan Marsden, Mattia Zanon, Mike D Rinderknecht

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Duration 2hrs Copenhagen, Denmark
1H-MR spectroscopy metabolite concentration as a marker of brain injury in progressive multiple sclerosis
Marco Ganzetti, Stanislas Hubeaux, Daria Rukina, Qing Wang, Anton Belousov, Agne Kazlauskaite, Sridar Narayanan, Roland G. Henry, Declan T. Chard, Giancarlo Comi, Licinio Craveiro, Douglas Arnold

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Duration 2hrs Copenhagen, Denmark
Ocrelizumab treatment and risk for composite disability progression in non-Hispanic Black and Hispanic or Latino individuals by self-identity and genetic ancestry with relapsing multiple sclerosis: findings from the OPERA I and II trials
Lilyana Amezcua, Devi Sai Sri Kavya Boorgu, Jake Oxendine, Ibraheem Abioye, Tushar Bhangale, Christopher Harp, Chien-Ju Lin, Nicolas Strauli, Akshaya Ramesh, Bruce Cree, Mitzi Williams, Xiaoming Jia

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Duration 2hrs Copenhagen, Denmark
Circulating B-cell and serum neurofilament light chain levels associated with progressive disease outcomes in Phase III trials of ocrelizumab in people with relapsing or progressive multiple sclerosis
Stephen L. Hauser, Nicolas Strauli, Anastasiia Raievska, Christopher Harp, Harold Koendgen, Heidemarie Kletzl, Ulrike Bonati, Xiaoming Jia, Ann E. Herman, Ludwig Kappos, Amit Bar-Or

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Duration 2hrs Copenhagen, Denmark
Disease activity before, during and after pregnancy in women with MS receiving ocrelizumab: an integrated analysis from 13 interventional clinical trials
Vukusic S, Perrin Ross A, Marfia G, Bove R, Dobson R, Hellwig K, Lin C-J, Pasquarelli N, Oreja-Guevara C

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Duration 2hrs Copenhagen, Denmark
Two-year Results of Patient-Reported Outcomes in Patients with Multiple Sclerosis Treated with Ocrelizumab in a Large Real-World Setting: MuSicalE Interim Analysis
Trojano M, Pesch V can, Alroughani R, Rovira A, Cutter G, Dzhenkova D, Hagenbuch N, Camerlingo S, Craveiro L, Hobart J

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Duration 2hrs Copenhagen, Denmark
Real-World persistence, adherence and treatment satisfaction in patients with relapsing-remitting multiple sclerosis treated with Ocrelizumab
Trojano M, van Pesch V, Alroughani R, Rovira A, Cutter G, Dzhenkova D, Hagenbuch N, Camerlingo S, Craveiro L, Hobart J

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Duration 2hrs Copenhagen, Denmark
Ocrelizumab Subcutaneous Injection in Patients with Multiple Sclerosis: Further Characterisation of the Benefit - Risk Profile from the OCARINA Clinical Development Programme
Newsome SD, Krzystanek E, Selmaj K, Goldstick L, Bermel R, Figueiredo C, Townsend B, Augustin A, Zecevic D, Giacobino C, Bortolami O, Shen YA, Schneble H-M, Centonze D

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Duration 2hrs Copenhagen, Denmark
The patient impact of 11 years of ocrelizumab treatment in multiple sclerosis: long-term data from the Phase III OPERA and ORATORIO studies
Hauser SL, Giovannoni G, Filippi M, Weber MS, Montalban X, Nicholas JA, Schneble HM, Wang Q, Kappos L

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Duration 2hrs Copenhagen, Denmark
Effectiveness and safety of satralizumab in a real-world clinical setting in Japan: Interleukin-6 receptor inhibition in Neuromyelitis Optica Spectrum Disorders: A six-month interim analysis of a multicenter medical chart review
Fujihara K, Isobe N, Miyamoto K, Niino M, Nakahara J, Hattori S, Yamamoto M, Kawachi I, Matsui N, Nohara C, Kokubun N, Chihara N, Misu T, Okada K, Yamashita K, Nagatsuka T, Adachi H, Nakashima I

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Duration 2hrs Copenhagen, Denmark
Method comparison of Elecsys and Simoa NfL assays in blood serum/plasma from patients with relapsing remitting/primary progressive multiple sclerosis
Hastreiter M, Babitzki G, Liess B, Bar-Or A, Cross A, Dias M, Gelfand J, Herman A, Jiang J, Winger RC, Jia X, Raposo C, Harp C

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