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Home Neuroscience AAIC 2025
Roche and Genentech at

AAIC 2025

July 27 - July 31
Toronto, Canada / Virtual (Hybrid)
aaic.alz.org
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Medical Materials
Agenda
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11:30 AM
Duration 9hrs Toronto, Canada
Evaluating the Impact on Diagnostic Performance and Healthcare Resource Utilization of Introducing a plasma rule-out test in the Alzheimer's Disease Diagnostic Pathway
Sophie Roth, Gustaf Ortsäter, Joana Amorim Freire
Neuroscience | Alzheimer Disease

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Duration 9hrs Toronto, Canada
Accuracy of cerebrospinal fluid biomarker ratios to determine amyloid positron-emission tomography status: a diagnostic test accuracy meta-analysis
Pablo Martinez-Lage, Eino Solje, Julian G. Martins, Sraboni Sarkar
Neuroscience | Alzheimer Disease

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Duration 9hrs Toronto, Canada
Investigating Differences in Patients Enrolled in a Clinical Study Based on Referral Type
Sophie Roth, Laura Schlieker, Sayuri Hortsch, Joana Amorim Freire, David Caley
Neuroscience | Alzheimer Disease

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Duration 9hrs Toronto, Canada
GABriella, a Phase 2a study investigating the gamma-secretase modulator RG6289 in individuals at risk for and at the prodromal stage of Alzheimer’s disease: baseline characteristics of the recruited participants
Rosanna Tortelli
Neuroscience | Alzheimer Disease

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Duration 9hrs Toronto, Canada
QUALITY OF RELATIONSHIPS BETWEEN INFORMAL CAREGIVERS AND PATIENTS WITH MILD COGNITIVE IMPAIRMENT
Elena Garcia-Arcelay
Neuroscience | Alzheimer Disease

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06:00 PM
Duration 90mins Room 718
Toward a new era of anti-amyloid antibodies: New mechanism of drug delivery and latest update on trontinemab
Catherine Mummery, Jeffrey L. Cummings, João A. Abrantes, David Agnew, Silke Ahlers, Fabien Alcaraz, Scarlett Barker, Tobias Bittner, Ruth Croney, Paul Delmar, Hideki Garren, Carsten Hofmann, Gregory Klein, Luka Kulic, Christopher Lane, Maddalena Marchesi, Jens Niewoehner, Gil D. Rabinovici, Daria Rukina, Stephen Salloway, Andres Schneider, Denise Sickert, Janice Smith, Reisa A Sperling, Franziska Schaedeli Stark, Hanno Svoboda, Angeliki Thanasopoulou, Matteo Tonietto, Roberto Villaseñor, Iris Wiesel, Jakub Wojtowicz, Stella Yilmaz, Henrik Zetterberg
Neuroscience | Alzheimer Disease

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06:05 PM
Duration 15mins Room 718
Next wave of innovation in Alzheimer’s disease therapeutics: The value of novel active transport mechanisms
Catherine Mummery, Roberto Villaseñor, Jens Niewoehner, Scarlett Barker, Luka Kulic
Neuroscience | Alzheimer Disease

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06:20 PM
Duration 15mins Room 718
Latest results from the dose-expansion part (Part 2) of the Brainshuttle™ AD study of trontinemab in people with Alzheimer’s disease
Luka Kulic, Fabien Alcaraz, Gregory Klein, Stephen Salloway, Carsten Hofmann, João A. Abrantes, Stella Yilmaz, Denise Sickert, Maddalena Marchesi, Jakub Wojtowicz, Andres Schneider, Ruth Croney, David Agnew, Silke Ahlers, Paul Delmar, Hanno Svoboda, Iris Wiesel
Neuroscience | Alzheimer Disease

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06:35 PM
Duration 15mins Room 718
Interim biomarker results for trontinemab, a novel Brainshuttle™ antibody in development for the treatment of Alzheimer’s disease
Gregory Klein, Gil D. Rabinovici, Henrik Zetterberg, Matteo Tonietto, Tobias Bittner, Daria Rukina, Fabien Alcaraz, Carsten Hofmann, Maddalena Marchesi, Jakub Wojtowicz, Ruth Croney, David Agnew, João A. Abrantes, Franziska Schaedeli Stark, Silke Ahlers, Paul Delmar, Hanno Svoboda, Iris Wiesel, Luka Kulic
Neuroscience | Alzheimer Disease

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11:30 AM
Duration 9hrs Toronto, Canada
Evaluating the Clinical Performance of the Elecsys pTau217 Plasma Immunoassay to Detect Amyloid Pathology in a Routine Clinical Practice Cohort
Sayuri Hortsch, Niels Borlinghaus, Alexander Jethwa, David Caley, Annunziata Di Domenico, Craig Ritchie
Neuroscience | Alzheimer Disease

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06:00 PM
Duration 90mins Metro Toronto Convention Centre Room 701
Clinical performance and effect of pre-analytical variation of plasma pTau217 alone versus the plasma pTau217/Aβ42 ratio for the identification of amyloid pathology
Christopher M. Rank, Joana Amorim Freire, Alexander Jethwa, Annunziata Di Domenico, Christina Rabe, Marc Suárez-Calvet, Colin L. Masters, Tobias Bittner
Neuroscience | Alzheimer Disease

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11:30 AM
Duration 9hrs Toronto, Canada
Equity in diagnosis through adequate clinical trial design in diagnostic performance studies
Imke Kirste, David Caley, Clara Quijano Rubio, Margherita Carboni
Neuroscience | Alzheimer Disease

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