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Home Oncology Lung Cancer

Lung Cancer

Lung cancer is the most common cancer in the world but still remains a challenge both in the clinical and research settings.

From studying the biology of lung cancer cells in the lab to leading clinical trials testing cutting-edge treatments, Roche is committed to addressing the medical need for therapies that extend patients’ lives.

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Mar 27 / Roche and Genentech
A phase II trial of tobemstomig (tobe) + platinum-based chemotherapy (chemo) vs pembrolizumab (pembro) + chemo in patients (pts) with untreated locally advanced or metastatic non-small cell lung cancer (NSCLC)
Efficacy and safety from the phase II BO44178 study of tobemstomig plus platinum-based chemotherapy versus pembrolizumab plus chemotherapy in patients with untreated locally advanced or metastatic NSCLC.
Oncology Lung Cancer ELCC-2025

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Mar 24 / Roche and Genentech
IMpower010: Digital pathology (DP) vs manual SP263 PD-L1 tumour cell (TC) scoring on whole imaging slides from patients (pts) with stage II-IIIA PD-L1 TC >=50% NSCLC
PD-L1 expression is predictive of anti–PD-1/–PD-L1 therapy benefit, but intratumoral heterogeneity, interobserver variability, multiple assays and scoring systems make its reliable evaluation problematic. A clone-agnostic artificial intelligence (AI) model for AI-based measurement of PD-L1 (AIM-PD-L1) was developed to address this challenge. In this exploratory analysis, we compared manual and AIM-PD-L1 scoring of SP263-stained tumour cell (TC) PD-L1 to assess the model’s ability to identify patients with stage II-IIIA PD-L1 TC ≥50% NSCLC from IMpower010 who can benefit from atezolizumab (NCT02486718) in an unbiased, automated manner.
Oncology Lung Cancer ELCC-2025

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Mar 6 / Roche and Genentech
Third OS interim analysis from BEAT-SC: Addition of bevacizumab to atezolizumab & chemotherapy in patients with ES-SCLC
The Phase III BEAT-SC study is evaluating bevacizumab + atezolizumab and carboplatin/cisplatin and etoposide (ACE) vs placebo + ACE in patients with untreated ES-SCLC from Japan and China. This presentation reports the third OS interim analysis and additional updated clinical data from BEAT-SC.
Oncology Lung Cancer JSMO-2025

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Mar 6 / Roche and Genentech
Resistance mechanisms and efficacy of first-line alectinib in patients with ALK+ non-small cell lung cancer
ALCURE is a real-world, observational, multi-center study exploring resistance mechanisms to first-line alectinib, prognostic factors of the efficacy of alectinib and optimal treatment sequencing in patients with advanced ALK-positive NSCLC. This oral presentation presents efficacy data with first-line alectinib and resistance mechanisms to alectinib from the second interim analysis of the ALCURE study.
Oncology Lung Cancer JSMO-2025

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Mar 6 / Roche and Genentech
Pharmacokinetics and safety of adjuvant alectinib in Japanese patients (pts) from ALINA with resected ALK-positive NSCLC
ALINA: Subgroup analysis investigating the pharmacokinetics and safety of adjuvant alectinib in Japanese patients with resectable stage IB-IIIA (UICC/AJCC 7th edition) ALK-positive NSCLC.
Oncology Lung Cancer JSMO-2025

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Mar 3 / Roche and Genentech
HORIZON-01: a phase I-III platform study evaluating the efficacy and safety of multiple therapies in patients with biomarker-defined locally advanced, unresectable stage III non-small cell lung cancer (NSCLC)
HORIZON-01 is an ongoing phase I–III, open-label, randomised platform study, evaluating the efficacy and safety of multiple targeted therapies (alectinib and entrectinib▼) compared with durvalumab, following concurrent radiotherapy (CRT) in patients with locally advanced, unresectable, stage III NSCLC. This trial-in-progress poster presents the trial design, key patient eligibility and study endpoints.
Oncology Lung Cancer BTOG-2025
Treatment management
  • Lung Cancer
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Sep 14 / Roche and Genentech
WCLC-2023-Meet the expert slides-screening and biomarker testing in resectable NSCLC
Slides from the early-stage NSCLC meet-the-expert session at WCLC 2023. Pan-Chyr Yang and Eran Choman cover the improved efficiency with LungFlag versus opportunistic selection in a theoretical East Asian lung cancer screening program, and then Jay M. Lee covers real-world biomarker testing and treatment patterns in resectable early-stage NSCLC.
Oncology Lung Cancer WCLC-2023

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Sep 14 / Roche and Genentech
WCLC-2023-Meet the expert slides-SCLC session
Slides from the SCLC meet-the-expert session at WCLC 2023 where Stephen V. Liu covers the five-year survival data in patients with ES-SCLC treated with atezolizumab in IMpower133 based on the IMbrella A extension study results.
Oncology Lung Cancer WCLC-2023

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Independent content
Sep 27 / Springer Healthcare
Managing ROS1 fusion-positive NSCLC in Europe and the USA
Luis Paz-Ares leads Jaime Schneider and Benjamin Besse in a discussion on the management of patients with ROS1 fusion-positive NSCLC in 2022.
Oncology Non-Small Cell Lung Cancer
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Upcoming congresses
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April 25 - April 30, 2025 / Illinois, USA
AACR 2025
Oncology Lung Cancer Colorectal Cancer Gastroesophageal Cancer Solid Tumours
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American Association for Cancer Research - 116th Annual Meeting
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May 3 - May 6, 2025 / San Diego, USA / Virtual (Hybrid)
DDW 2025
Inflammatory Disease Inflammatory Bowel Disease
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Digestive Disease Week - 2025
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Disease Education

The role of the Blood-Brain Barrier in lung cancer treatment

Some types of cancer, such as anaplastic lymphoma kinase (ALK)-positive non-small cell lung cancer (NSCLC), frequently spread into the brain and central nervous system. A key challenge of treating these brain metastases is the blood-brain barrier, which you can learn more about in this video.

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Unleashing the T-Cell army

Watch this video that describes the cancer immunity cycle and how a tumour interacts with the human immune system.

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