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Hepatitis C virus infection

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Apr 14 / Roche
Plasma separation card as an alternative sampling method for quantitative HCV RNA testing with high comparability to EDTA plasma
The World Health Organization recommends simplified diagnostic methods to facilitate HCV RNA testing access in decentralized settings, e.g., facilitating specimen stability in extreme conditions. This study evaluated the clinical utility of dried plasma spots collected with the Cobas Plasma Separation Card (PSC) as an alternative to EDTA plasma for HCV RNA detection and quantification using the Cobas HCV assay.
Infectious Disease Hepatitis C virus infection ESCMID-2025

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Mar 28 / Roche
Evaluation of blood droplet volumes on the Cobas Plasma Separation Card for HCV RNA testing in resource-limited settings
Detection of viral RNA is essential for diagnosis of hepatitis C virus (HCV). Collection and preservation of plasma, the preferred specimen type for HCV RNA testing, can present challenges in remote and resource-limited areas. The Cobas Plasma Separation Card (PSC) is a matrix for preparing dried plasma spots for PCR analysis with no cold chain requirements, facilitating sample collection in remote, underserved areas. The PSC is designed to use capillary blood (140 µL) collected through a fingerstick and capillary tube collection. This study explored qualitative and quantitative HCV RNA detection with the PSC spotted with different venous blood volumes, compared with results from plasma samples.
Infectious Disease Hepatitis C virus infection APASL-2025
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