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Genitourinary (GU) Cancer

Roche is leading the investigation of new options for patients suffering from genitourinary cancer, exploring the potential of cancer immunotherapy and treatment tailored to individuals.

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Dec 4 / Roche and Genentech
Disease-free survival and overall survival in patients with high-risk muscle-invasive bladder cancer who have persistent circulating tumor DNA-negative biomarker status post-cystectomy: IMvigor011 study surveillance analysis
This poster reports DFS and OS outcomes in patients with high-risk MIBC who had persistent ctDNA− status post-cystectomy (through 12 months) using data from surveillance arm of the global, double-blind, randomized Phase III IMvigor011 study. 

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Oct 23 / Roche and Genentech
A global, multicentre, open-label, randomised phase II trial of tobemstomig (tobe) with or without tiragolumab (tira) vs atezolizumab (atezo) in patients (pts) with untreated metastatic urothelial cancer (mUC) ineligible for platinum-based chemotherapy (chemo)
This poster describes the design of a global, open-label, randomised Phase II study evaluating tobemstomig with or without tiragolumab compared with atezolizumab in platinum-ineligible patients with previously untreated, locally advanced or mUC. The study rationale, eligibility criteria, endpoints and enrolment details are reported.

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Oct 22 / Roche and Genentech
A phase II study investigating the safety and efficacy of neoadjuvant atezolizumab in non-urothelial, muscle invasive bladder cancer (ABACUS-2)
This oral presentation reports clinical outcomes with neoadjuvant atezolizumab in patients with invasive non-conventional UC subtypes from the ABACUS-2 clinical study. Data presented include pCR (primary endpoint) and safety.

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Feb 17 / Roche and Genentech
Early efficacy results from atezolizumab with split-doses of cisplatin plus gemcitabine in patients with locally advanced or metastatic urothelial carcinoma (SOGUG-AUREA)
AUREA poster description: This poster reports data from the phase II trial SOGUG-AUREA, evaluating first-line atezolizumab plus split-dose cisplatin in patients with locally advanced or metastatic urothelial carcinoma who are ineligible for full doses of platinum-based chemotherapy. Early efficacy and safety data are presented.
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