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CHARCOT 2023

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Nov 27 / Roche
Watch: Federated Architecture and Learning: Are we on the Cusp of a New (Approach To) Understanding Biological and Clinical Data?
An interactive symposium where the expert panel navigate the paradigm shift of hypothesis-driven research to data-driven research with machine learning, federated architecture and federated learning. The faculty discuss how these concepts can be utilised to accelerate our understanding of multimodal big data across MS and introduced INTONATE-MS, a federated architecture to drive collaborative research between academia and industry.(Full recording).

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Nov 27 / Roche
Federated Architecture and Learning: Are we on the Cusp of a New (Approach To) Understanding Biological and Clinical Data?
An interactive symposium where the expert panel navigate the paradigm shift of hypothesis-driven research to data-driven research with machine learning, federated architecture and federated learning. The faculty discuss how these concepts can be utilised to accelerate our understanding of multimodal big data across MS and introduced INTONATE-MS, a federated architecture to drive collaborative research between academia and industry. (Symposium slides).

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Nov 9 / Roche and Genentech
Cerebrospinal Fluid and MRI Analyses of Fenebrutinib Treatment in Multiple Sclerosis Reveal Brain Penetration and Early Reduction of New Lesion Activity: Results from the Phase II FENopta study
Bruton’s tyrosine kinase (BTK) is implicated in peripheral and central nervous system inflammation in multiple sclerosis (MS) and is a therapeutic target for relapsing and progressive disease. Fenebrutinib is a potent, highly selective, noncovalent, reversible BTK inhibitor under investigation for MS. The objective of FENopta, a randomised, double-blind, placebo-controlled, Phase 2 trial (NCT05119569), was to evaluate efficacy and safety of fenebrutinib in relapsing MS and evaluate the early impact of fenebrutinib on MRI outcomes and soluble markers of disease activity and progression.
11:30 AM
Duration 60mins Baveno, Italy
Cerebrospinal Fluid and MRI Analyses of Fenebrutinib Treatment in Multiple Sclerosis Reveal Brain Penetration and Early Reduction of New Lesion Activity: Results from the Phase II FENopta study
Amit Bar-Or, Michal Dufek, Hrvoje Budincevic, Jelena Drulovic, Mario Habek, Le H Hua, Martin S Weber, Piia Thomas, Julie Napieralski, David Clayton, Denison Kuruvilla, Qi Qi, Yan Xu, Alexandra Goodyear, Jiwon Oh

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05:15 PM
Duration 5mins Baveno, Italy
Federated Architecture and Learning: Are we on the cuspo of a New (Approach To) Understanding Biological and Clinical Data?
Jiwon Oh, Heinz Wiendl

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