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IFCC 2023

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May 22 / Roche
Relationship between SARS-CoV-2 viral load, antigen positivity, and infectious titre
This study compares the performance of the Elecsys SARS-CoV-2 Antigen assay with quantitative tests for viral load (RT-PCR) and for infectivity (viral culture) using samples collected in a randomized, controlled trial.

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May 21 / Roche
GAAD and GALAD algorithmic scores demonstrate equivalent clinical performance for hepatocellular carcinoma (HCC) surveillance in prospective,multicenter, case-control studies
The GALAD algorithm, combining gender (sex) and age plus serum biomarkers alpha-fetoprotein (AFP), Lens culinaris agglutinin-reactive fraction of AFP (AFP-L3) and protein-induced by vitamin K absence-II (PIVKA-II), is a promising aid in the detection of early-stage hepatocellular carcinoma (HCC). This poster presents data from two independent, prospective, case-control studies (STOP-HCC-MCE and STOP-HCC-Panel B). These studies compared the clinical performance of the GALAD and the novel GAAD (gender [sex], age, AFP and PIVKA-II) algorithm for differentiating between early-stage HCC and benign chronic liver disease.

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May 21 / Roche
Robustness of cerebrospinal fluid (CSF) amyloid-β 1–42/amyloid-β 1–40 (Aβ42/Aβ40) and phosphorylated tau/amyloid-β 1–42 (pTau/Aβ42) biomarker ratios in classification of amyloid positron emission tomography (PET) positivity in routine clinical use
This study evaluated and compared the robustness of cerebrospinal fluid biomarker ratios, Aβ42/Aβ40 and pTau/Aβ42, in the diagnostic evaluation of Alzheimer’s disease in people with mild cognitive impairment or subjective cognitive decline, with respect to a hypothetical theoretical bias expected in routine clinical use.