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Angiogenesis 2024

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Feb 3 / Roche and Genentech
Microperimetry Endpoints: An Updated Analysis of the Lampalizumab Clinical Trial Data
Microperimetry is an established technique to assess visual function over time used in clinical trials in eyes with geographic atrophy due to non-exudative age-related macular degeneration. Change in retinal sensitivity at perilesional points has been shown to demonstrate greater sensitivity compared to the traditional method, which analyzes the average sensitivity across all points. For glaucoma treatments, the FDA suggests that clinically meaningful mean improvement of ≥7 dB post treatment from baseline in 5 or more predefined loci (areas), sustainable over time, is an acceptable endpoint. Using this threshold, we assessed time to 7-dB loss averaged over at least 5 or more predefined loci in the perilesional area in the lampalizumab MP population and the feasibility of using these endpoints for future clinical trials.

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Feb 3 / Roche and Genentech
Emerging Imaging and Biological Markers Supporting Angiopoietin-2 in nAMD and DME
This presentation reports the results of analyses from the YOSEMITE/RHINE and TENAYA/LUCERNE trials that evaluated clinical biomarkers of dual Ang-2/VEGF-A inhibition with faricimab▼ vs anti-VEGF inhibition alone with aflibercept. Biomarkers that were assessed included CST, intraretinal fluid, retinal pigment epithelial detachments, macular leakage, hyperreflective foci, and epiretinal membranes.

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Feb 3 / Roche and Genentech
Targeting Ang2 and VEGF - Biology, Pharmacokinetics and Latest Clinical Data in nAMD and DME
This presentation summarizes the results of faricimab▼ phase 3 trials, TENAYA/LUCERNE and YOSEMITE/RHINE, for the treatment of nAMD and DME respectively. Data presented demonstrates that dual Ang-2/VEGF-A inhibition with faricimab▼ improves disease fluid control with extended durability Vs anti-VEGF inhibition alone and may allow for potential interval extension to Q20W dosing.
05:40 PM
Duration 10mins Virtual
Microperimetry Endpoints: An Updated Analysis of the Lampalizumab Clinical Trial Data
Ip M

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10:50 PM
Duration 10mins Virtual
Targeting Ang2 and VEGF - Biology, Pharmacokinetics and Latest Clinical Data in nAMD and DME
Lim J

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11:00 PM
Duration 10mins Virtual
Emerging Imaging and Biological Markers Supporting Angiopoietin-2 in nAMD and DME
Singh R

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11:10 PM
Duration 10mins Virtual
Faricimab▼ in RVO: 72-Week Results From the BALATON and COMINO Phase 3 Studies
Tadayoni R

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11:20 PM
Duration 10mins Virtual
Voyager Study- Update on Faricimab▼ in the Real World
Guymer R

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01:10 AM
Duration 10mins Virtual
The Path Forward for PDS: Technical Data Supporting Device Improvements and Septum Dislodgement Mitigation
Pieramici D

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01:20 AM
Duration 10mins Virtual
The Impact of Continuous Delivery of Ranibizumab With PDS on Retinal Nonperfusion in Diabetic Retinal Disease
Campochiaro P

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